Butyrolactone I

Code: 203988-200UG D2-231

Biochem/physiol Actions

Reversible: no

Target IC50: 680 nM against Cdk1

Product does not compete with ATP.

Primary Targetp34cdk1/cyclinB

Ce...


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€226.99 EACH
Discontinued
€279.20 inc. VAT

Biochem/physiol Actions

Reversible: no

Target IC50: 680 nM against Cdk1

Product does not compete with ATP.

Primary Targetp34cdk1/cyclinB

Cell permeable: yes

General description

A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G1/S and G2/M transitions. Inhibits p34cdk1/cyclinB (Cdk1; IC50 = 680 nM). Also selectively inhibits Cdk2 and Cdk5 kinases. Has little effect on casein kinase I, casein kinase II, EGF receptor kinase, MAP kinase, PKA, and PKC. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Also blocks Fas-induced apoptosis in HL-60 cells and shows antitumor effects on human lung cancer cell lines.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Furukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.Nishio, K., et al. 1996. Anticancer Res. 16, 3387.Kitagawa, M., et al. 1994. Oncogene 9, 2549.Kitagawa, M., et al. 1993. Oncogene 8, 2425.

Packaging

200 µg in Plastic ampoule

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Warning

Toxicity: Standard Handling (A)

assay≥99% (TLC)
colorwhite
formsolid
InChI keyFPVUCBMBMUHRDX-XMMPIXPASA-N
InChI1S/C24H24O7/c1-14(2)4-6-17-12-15(5-11-19(17)26)13-30-23(29)24(3)20(21(27)22(28)31-24)16-7-9-18(25)10-8-16/h4-5,7-12,25-27H,6,13H2,1-3H3/t24-/m1/s1
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
storage conditionprotect from light, OK to freeze
storage temp.−20°C
Cas Number87414-49-1
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